Souza, Ernane





Dr. Souza is a pharmacist and medicinal chemist, with broad experience in drug discovery and development. He joined the faculty at the Gregory School of Pharmacy after completing his postdoctoral fellowship in Clinical Pharmacy Translational Science at the University of Michigan. Dr. Souza earned his Ph.D. degree in Medicinal & Natural Products Chemistry from the University of Iowa, and his Bachelor of Pharmacy degree from the Federal University of Juiz de Fora, in Brazil. While pursuing his professional pharmacy degree, Dr. Souza completed one year of research and coursework at the University of Salamanca School of Pharmacy, in Spain.

Besides having experience in the pharmaceutical industry, healthcare regulatory affairs, hospital, compounding, and community pharmacies, Dr. Souza has acquired additional pharmacy training at the University of Iowa Hospitals and Clinics. While practicing pharmacy, he provided pharmaceutical care to ethnically diverse groups and counseled patients in four languages (English, Spanish, Portuguese and French). He has experience managing multiple clinical trials sponsored by Pharma and philanthropic foundations. Dr. Souza is currently a registered pharmacist in the states of Iowa and Michigan. The skills he gained through intensive training in both basic and clinical sciences allow him to perform true bench-to-bedside research by contributing to the development of new medicines as well as to the optimization of existing pharmacotherapy regimens.

His current research combines medicinal chemistry with clinical pharmacology to translate basic laboratory findings into clinically relevant applications. While completing his graduate studies, Dr. Souza discovered reaction byproducts and characterized them as a new class of direct modulators of thrombin, an important enzyme involved in blood coagulation. This serendipitous discovery led to the development of a series of structural analogues of the newly found molecules that contributed to further understanding some of the essential requirements for thrombin regulation. This work is currently under publication embargo for intellectual property protection. At PBA, one of the programmatic areas of Dr. Souza’s research is the lead optimization of thrombin inhibitors toward the development of a promising new class of safer anticoagulants to overcome the bleeding risks associated with current anticoagulation pharmacotherapy. In addition, Dr. Souza provides support for a variety of highly collaborative, multidisciplinary translational research projects by integrating biological and chemical concepts to address unmet medical needs in order to advance healthcare and ultimately improve patients’ quality of life.

Dr. Souza has served as an instructor on multiple courses at the University of Michigan College of Pharmacy. At PBA, he teaches Medicinal Chemistry, Pharmacokinetics, and Cardiovascular Pharmacotherapy modules within the Doctor of Pharmacy curriculum. During his free time, he likes to spend time with his wife, Larissa, doing outdoor activities and taking road trips to visit National Parks in the US. He and Larissa are active members of Maranatha Christian Church and are committed to spread the gospel throughout the world.


B.Pharm., Federal University of Juiz de Fora (UFGF) – Brazil; Ph.D., University of Iowa.

Joined PBA in